Mixed Micelle Formation of Bile Salt Mixtures
نویسندگان
چکیده
منابع مشابه
Kinetics of the micelle-to-vesicle transition: aqueous lecithin-bile salt mixtures.
Important routes to lipid vesicles (liposomes) are detergent removal techniques, such as dialysis or dilution. Although they are widely applied, there has been only limited understanding about the structural evolution during the formation of vesicles and the parameters that determine their properties. We use time-resolved static and dynamic light scattering to study vesicle formation in aqueous...
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Bile salt/phospholipid mixed micelles (MMs) are potent carriers used for oral absorption of drugs that are poorly soluble in water; however, there are many limitations associated with liquid formulations. In the current study, the feasibility of preparing bile salt/phospholipid MM precursor (preMM) pellets with high oral bioavailability, using fluid-bed coating technology, was examined. In this...
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The solubility of fatty acids and cholesterol in bile does not appear to be due to the formation of soluble compounds of the choleic acid type. The bile is made up chiefly of the conjugated bile salts and such compounds with conjugated bile acids or salts have not been isolated (1). It is generally agreed that the solution of oils in aqueous solutions of soaps is associated with the micelle for...
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Tauroursodeoxycholate (TUDC), a relatively hydrophilic bile salt, reduces disruption of cholesterol-rich membranes by more hydrophobic bile salts such as taurocholate (TC), taurochenodeoxycholate (TCDC), or taurodeoxycholate (TDC). We examined the interactions of these bile salts in adsorption to large unilamellar vesicles to determine whether TUDC may stabilize membranes by preventing adsorpti...
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Experimental data are presented on the enhanced solubilities and micelle/water partition coefficients of 14 polychlorinated biphenyls (PCBs) in solutions of the bile salts sodium taurocholate (TC) and sodium taurodeoxycholate (TDC) below and above the critical micellar concentration (CMC). Solubilities of PCBs in micellar solutions above the CMC depend linearly on bile salt concentration and th...
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ژورنال
عنوان ژورنال: Journal of Japan Oil Chemists' Society
سال: 1990
ISSN: 1884-2003
DOI: 10.5650/jos1956.39.8_542